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Title :次世代型2-5Aアンチセンス核酸の創製とその遺伝情報の制御
Authors :北出, 幸夫
Issue Date :2004
Table of contents :9-15p: Ueno Y. et al., Synthesis of Antisense Oligonucleotides Carrying Modified 2-5A Molecules at Their 5'-Termini and Their Properties. Bioconjugate Chem.. 2003 14: 690-696
16-18p: Ueno Y. et al., Synthesis of Double-Headed 2-5A-Antisense Chimeras and Their Ability to Activate Human RNase L. Bioorganic & Medicinal Chemistry Letters. 2003 13:3959-3961
19-23p: Ueno Y. et al., A Specific Substrate-Inhibitor, a 2'-Deoxy-2'-fluorouridine-Containing Oligoribonucleotide,against Human RNase L. Bioorganic & Medicinal Chemistry. 2003 11: 5069-5073
24-31p: Nakanishi M. et al., Contribution of Try712 and Phe716 to the activity of human RNase L. Eur.J.Biochem. 2004 271: 2737-2744
32-35p: Ueno Y. et al., Synthesis of 2',5'-oligoadenylate analogs containing an adenine acyclonucleoside and their ability to activate human RNase L. Bioorganic & Medicinal Chemistry Letters. 2004 14: 4431-4434
36-45p: Tanaka N. et al., Structural basis for recognition of 2',5'-linked oligoadenylates by human ribonuclease L. The EMBO Journal. 2004 23(20): 3929-3938
46-49p: Tanaka N. et al., Crystallization of the N-Terminal ankyrin repeat domain of the 2-5A-dependent endoribonuclease, RNase L. Protein and Peptide Letters. 2005 12(4): 387-389
50-57p: Nakanishi M. et al., 2-5A Induces a Conformational Change in the Ankyrin-Repeat Domain of RNase L. Proteins-Structure Function and Bioinformatics. 2005 60(1): 131-138
58-67p: Hatanaka K. et al., Interferon-α and antisense K-ras RNA combination gene therapy against pancreatic cancer. The Journal of gene medicine. 2004 6: 1139-1148
Abstract :平成15年度-平成16年度年度科学研究費補助金 (基盤研究(B)(2) 課題番号15390036) 研究成果報告書
Type Local :研究報告書
URI :http://hdl.handle.net/20.500.12099/736
Appears in Collections:Grants-in-Aid for Scientific Research - Engineering